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富马酸二甲酯

CAS No. : 624-49-7

MCE 国际站：Dimethyl fumarate

产品活性：Dimethyl fumarate (DMF) 是一种具有口服活性且可透过血脑屏障的 Nrf2 激活剂，可诱导抗氧化剂基因表达上调。Dimethyl fumarate 通过 GSH 耗竭/ROS 升高/MAPKs 激活途径诱导结肠癌细胞坏死，并诱导细胞自噬 (autophagy)。Dimethyl fumarate 可用于多发性硬化症的研究。

研究领域：NF-κB  |  Immunology/Inflammation  |  Anti-infection  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Keap1-Nrf2  |  Reactive Oxygen Species  |  HIV  |  Autophagy  |  Endogenous Metabolite

结构分类：其他类

In Vitro: Dimethyl fumarate (DMF; 20-200 μM; 24 hours) treatment dose-dependently reduces the viability of SGC-7901, HT29, HCT116 and CT26 cancer cells.
Dimethyl fumarate (DMF; 100 μM; 3-24 hours) significantly activates JNK, p38 and ERK in CT26 cells.
Dimethyl fumarate induces necroptosis in colon cancer cells and the mechanism involves GSH depletion, an increase in ROS and activation of MAPKs-mediated signalling.
Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs NF-κB signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling.
Dimethyl fumarate (DMF), an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release.

In Vivo: Dimethyl fumarate (DMF; 50 mg/kg; oral gavage; daily; for 7 days) treatment is shown to upregulate the mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice.

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