N,N-Dipropyldopamine hydrobromide - MedChemExpress 生物.医药.天然产物

N,N-Dipropyldopamine hydrobromide - MedChemExpress

2023年11月06日 09:54 生物.医药.天然产物

关键词： N,N-Dipropyldopamine hydrobromide

简介：N,N-dipropyldopamine 是一种具有抑癌活性的谷氨酸释放 (glutamate release) 的高效抑制剂。谷氨酸释放增加导致癌症引起的骨痛cancer-induced bone pain (CIBP)。N,N-dipropyldopamine 能缓解癌症引起的骨痛。

Cat. No.：HY-132219

Drug_Names：N,N-Dipropyldopamine hydrobromide

纯度：

生物活性：N. N-dipropyrldopamine is a potent inhibitor of glutamate release and has anticancer activity. The increase of glutamate secretion leads to cancer-induced bone pain (CIBP). N. N-dipropyrldopamine plays an analgesic role in CIBP^[1].

IC50 & Target：

cystine/glutamate transporter (XC-)[1]IC50:25.45 μM (cystine/glutamate transporter, XC-)[1]

体外研究：

N,N-dipropyldopamine (10-200 μM， 48 小时) 显著抑制 MDA-MB-231, MCF-7, Mat-Ly-Lu 细胞生长， IC₅₀ 分别为 25.45, 26.3, 28.45 μM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231, MCF-7 and Mat-Ly-Lu
Concentration:	0-200 μM
Incubation Time:	48 h
Result:	Inhibited cell growth with IC₅₀ values of 25.45 μM (MDA-MB-231), 26.3 μM (MCF-7), 28.45 μM (Mat-Ly-Lu).

分子量：318.25

Formula：C₁₄H₂₄BrNO₂

CAS No.：65273-66-7

运输条件：Room temperature in continental US; may vary elsewhere.

储存方式：

Please store the product under the recommended conditions in the Certificate of Analysis.

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