代谢型谷氨酸受体激动剂，trans-ACPD 是一种代谢型受体激动剂，促进钙离子活动及产生内向电流。

中文名称
(±)-trans-ACPD
英文名称
(±)-trans-ACPD
英文别名
( /-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID;(±)-TRANS-ACPD;Trans-(±)-ACP;Trans-(±)-ACPD;trans-(±)-ACPD monohydrate;(+/-)-TRANS-ACPD;(±)-1-AMinocyclopentane-trans-1,3-dicarboxylicacid;(1SR,3RS)-1-aminocyclopentane-1,3-dicarboxylic acid;TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID;TRANS-(+/-)-ACPD;TRANS(+-)-ACPD EXCITATORY AMINO ACID;TRANS-ACPD
Cas No.
67684-64-4
分子式
C7H11NO4
分子量
173.17

生物活性
trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
性状
Solid
IC50 & Target[1][2]
mGluR
 
体外研究(In Vitro)
Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC50 values are 480-850 μM).
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.

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