产品货号：B656425
产品名称：Boc-3-hydroxy-1-adamantyl-glycine
Synonyms:(2R)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic Acid; (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxy-tricyclo[3.3.1.13,7]decane-1-acetic Acid
CAS号：1334321-39-9
分子式：C₁₇H₂₇NO₅
Appearance:White to Off-White Solid
Melting Point:>280°C (dec.)
分子量：325.4
Storage:-20°C
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用：Boc-3-hydroxy-1-adamantyl-glycine is an impurity of Saxagliptin (S143500), which is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
参考文献：Feng, J., et al.: J. Med. Chem., 50, 2297 (2007),
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