Cesium Gluconate (Cs-Gluc)

Product overview

• Name
  Cesium Gluconate (Cs-Gluc)
• Short description
  Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology.
• Biological description

  Cesium gluconate is used as a component in cesium gluconate-based internal (intracellular) solutions for patch clamp electrophysiology.

  Cesium blocks potassium (K⁺) channels and K⁺ currents to help provide a good space clamp.

  Cesium-gluconate based internal solutions are commonly used for voltage-clamp applications and are useful when studying EPSCs (excitatory postsynaptic currents) / IPSCs (inhibitory postsynaptic currents).

• Alternative names
  CeGlu, Cs-Gluc, Cs-Gluconate, CsGluconate
• Biological action
  Blocker
• Customer comments

  We prepared a variety of Cesium Gluconate-based intracellular solutions to record excitatory synaptic currents from brain slices using whole-cell patch clamp. All solutions prepared using the Hello Bio Cesium Gluconate performed exactly as expected, saving us the time and trouble of synthesising the salt “in-house".

Properties

• Chemical name
  D-Gluconic acid cesium salt
• Molecular Weight
  328.05
• Chemical structure
  
• Molecular Formula
  C₆H₁₁CsO₇
• PubChem identifier
  0
• SMILES
  O[C@H]([C@@H](O)C(=O)O[Cs])[C@H](O)[C@H](O)CO
• Source
  Synthetic
• InChi
  InChI=1S/C6H12O7.Cs/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
• InChiKey
  IDGWYOYDRLQSAS-JJKGCWMISA-M
• Appearance
  White solid

  Storing and Using Your Product

• Storage instructions
  +4°C
• Solubility overview
  Soluble in water (200 mM)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

  References for Cesium Gluconate (Cs-Gluc)

• Analysis of the effects of cesium ions on potassium channel currents in biological membranes.

  Clay and Shlesinger (1984) J Theor Biol 107(2) : 189-201
  PubMedID: 6325824

• Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.

  Adelman and Senft (1966) J Gen Physiol 50(2) : 279-93
  PubMedID: 11526829

• An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.

  French and Shoukimas (1985) J Gen Physiol 85(5) : 669-98
  PubMedID: 2582077