产品英文名称：
Recombinant Human N-Myc Downstream Regulated 1

英文简称:
NDRG1

中文名称:
重组人N-myc下游调节基因1

背景资料:
NDRG1 is a cytoplasmic protein that is involved in stress responses， hormone responses， cell growth， and di大肠杆菌中重组表达erentiation. NDRG1 is one of 4 members of the NDRG ?/?-hydrolase family. NDRG1 is classified in databases as a tumor suppressor and heavy metal-response protein. NDRG1’s functions include cell-cycle regulation， cellular di大肠杆菌中重组表达erentiation， apoptosis， hypoxia response and metal-ion sensing. NDRG1 is also essential for p53-mediated caspase activation and apoptosis. The NDRG1 is a Rab4a e大肠杆菌中重组表达ector that is involved in vesicular recycling of E-cadherin. NDRG1 is ubiquitous； it is expressed most notably in placental membranes and prostate， kidney， small intestine， and ovary tissues. NDRG1 has reduced expression in adenocarcinomas compared to normal tissues.NDRG1 gene mutations are reported to be the cause for hereditary motor and sensory neuropathy-Lom （HMSNL）， which is a severe autosomal recessive form of Charcot- Marie-Tooth （CMT） disease. In addition， decreased NDRG1 expression in glioma is linked to tumor progression. On the other hand， overexpression of NDRG1 is connected to malignant status of esophageal cancer. NDRG1 may also have a role in portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.

产品描述:
NDRG1 Human Recombinant fused with 8 amino acid His tag at C-terminus produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 402 amino acids （1-394 a.a.） and having a molecular mass of 43.9 kDa.The NDRG1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGTRSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSCLEHHHH HH.

溶解建议:
Sterile Filtered colorless solution. The NDRG1 solution contains 20mM Tris-HCl buffer （pH8.0）， 0.1mM PMSF and 10% Glycerol.

保存建议：
NDRG1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please prevent freeze-thaw cycles.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。