本公司提供科研BBC3/PUMAp53正向细胞凋亡调控因子抗体，抗体质量可靠，订购BBC3/PUMAp53正向细胞凋亡调控因子抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：p53正向细胞凋亡调控因子抗体
英文名称：Anti-BBC3/PUMA
货号：bs-1573R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, pig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：PUMA is an essential mediator of p53-dependent and p53-independent apoptosis. It is localized in the mitochondria and induces cytochrome c release and activates the rapid induction of programmed cell death. There are two isoforms, alpha and beta. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Function : Essential mediator of p53-dependent and p53-independent apoptosis.Subunit : Belongs to the Bcl-2 family.Subcellular Location : Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.Tissue Specificity : Ubiquitously expressed.PUMA在由p53诱导而经历细胞凋亡的细胞中被p53活化。在线粒体，PUMA 诱导细胞色素C的释放和激活对细胞凋亡的快速诱导。PUMA 与Bcl2、Bcl-XL、类Bcl2-1蛋白相互作用，促使线粒体易位和BAX的多聚化。PUMA在通过依赖细胞色素C/APAF1 途径介导p53诱导的细胞死亡中也发挥作用。