本公司提供科研PIGR多聚免疫球蛋白受体抗体,抗体质量可靠,订购PIGR多聚免疫球蛋白受体抗体请联系在线客服或者销售人员。 抗体参数如下>>>> 中文名称:多聚免疫球蛋白受体抗体 英文名称:Anti-PIGR 货号:bs-6061R 抗体来源:兔 克隆类型:多克隆 蛋白分子量:predicted molecular weight: 82kDa 纯化方法:affinity purified by Protein A 交叉反应:hu, mo, rat, cow, dog 测试应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 产品背景介绍:PIGR is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Secretory component: Secreted.Similarity : Contains 5 Ig-like V-type (immunoglobulin-like)多聚免疫球蛋白受体(pIgR)属Ⅰ型跨膜糖蛋白,可与多聚免疫球蛋白A和多聚免疫球蛋白M特异性结合,通过穿胞转运,将它们从上皮细胞基底侧膜转运到顶膜,并最终分泌到外分泌液中去. 在此过程中,多聚免疫球蛋白受体的细胞外段被水解,释放出与多聚免疫球蛋白A或多聚免疫球蛋白M相结合的细胞外段(又称为分泌成分). 分泌成分是sIgA分子的重要组成部分,直接参与sIgA的粘膜防御功能,而且在被动粘膜免疫中也有重要作用. 多聚免疫球蛋白受体通过介导细胞内多聚免疫球蛋白的转运,可以在粘膜的腔面阻止病原体粘附,在上皮细胞内中和病毒,也可以将固有层内的抗原分泌出去.