生物学描述Selective angiotensin-(1-7) antagonist. Shows potent Mas receptor binding affinity (IC50 = 0.3 nM). Antidiuretic and vasoconstrictor agent. Active in vivo and in vitro.
纯度> 93%
性能
分子量872.98
化学结构
分子式C39H60N12O11
CAS编号159432-28-7
序列DRVYIHA (Modifications: Ala-7 = D-Ala)
存放说明Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in water
处理
A 779 (ab142820)参考文献
This product has been referenced in:
Xue H et al.Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells.Regul Pept177:12-20 (2012). Read more (PubMed: 22561449) »
Maia LG et al.Angiotensin-(1-7) antagonist A-779 attenuates the potentiation of bradykinin by captopril in rats.J Cardiovasc Pharmacol43:685-91 (2004). Read more (PubMed: 15071356) »
Santos RA et al.Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.Brain Res Bull35:293-8 (1994). Read more (PubMed: 7850477) »
