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本试剂(PP1)
仅供科研实验使用,不得用于其他用途！
简介：
货 号：P-6420
名 称：PP1
别 名：PP1 Free Base
C A S ：172889-26-8
分子量：281.36
分子式：C16H19N5
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
文 献：PP1 selectively and potently inhibited the activity of Src family kinases p56lck and p59fynT with IC50 values of 5 nM and 6 nM, respectively. It inhibited anti-CD3-induced T cell tyrosine phosphorylation, TcR-induced T cell proliferation, and IL-2 gene induction. Hanke, J.H., et al. "Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation." J. Biol. Chem. 271: 695-701 (1996).PP1 has been demonstrated to reduce the expression of vascular endothelial growth factor (VEGF), protect the blood-brain barrier, reduce brain edema immediately after subarachnoid hemorrhage, and offer cerebral protection against stroke. Jadhav, V., et al. "Neuroprotection against surgically induced brain injury." Surg. Neurol. 67: 15-20 (2007).PP1 and its analog, PP2, are powerful inhibitors of TGF-β-induced cell migration and invasion in vitro. Both of them may prevent metastatic spread in late-stage pancreatic ductal adenocarcinoma and non-small cell lung cancer. Bartscht, T., et al. "The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells." Cancer Chemother. Pharmacol. 70: 221-230 (2012).
