粘液样脂肪肉瘤蛋白FUS1抗体品牌价格,详情介绍-960化工网

粘液样脂肪肉瘤蛋白FUS1抗体品牌

价格：¥1000 - 3500

品牌：上海博湖

产地：进口、国产

最新更新日期：2021-07-15 19:53

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联系人：韩丽君

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产品属性

抗体名	粘液样脂肪肉瘤蛋白FUS1抗体品牌

抗体英文名

Anti-TLS/FUS

靶点

详见说明书

浓度

1mg/1ml

应用范围	WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

宿主

详见说明书

供应商

上海博湖

数量

大量

级别

详见说明书

目录编号

详见说明书

抗原来源

Rabbit

保质期

详见说明书

适应物种

详见说明书

标记物

详见说明书

克隆性

多克隆

保存条件	Store at -20 °C

形态

详见说明书

亚型

IgG

免疫原	KLH conjugated synthetic peptide derived from human TLS

规格	0.2ml/200μg

产品说明

粘液样脂肪肉瘤蛋白FUS1抗体品牌Anti-Skp2/FITC 荧光素标记细胞S相激酶相关蛋白抗体IgGMulti-class antibodies规格： 0.2ml
BDNF (Brain-derived Neurotrophin factor) 脑源神经营养因子(脑衍化神经营养因子)(多肽片断抗原)Multi-class antibodies规格： 0.5mg
合成酶-2抗体 Anti-NOS-2/iNOS 0.1ml
5-HT/5 Hydroxy Tryptophan 英文名称： 5羟抗体 0.1ml
EME1 英文名称：减数分裂内切酶EME1抗体 0.2ml
Rhesus antibody Rh phospho-P53(Ser6) 化抑制基因P53抗体规格 0.1ml
BDNF (Brain-derived Neurotrophin factor) 脑源神经营养因子(脑衍化神经营养因子)(多肽片断抗原)Multi-class antibodies规格： 0.5mg
英文名称 Anti-TLS/FUS
中文名称粘液样脂肪肉瘤蛋白FUS1抗体品牌

别名 75 kDa DNA pairing protein; 75 kDa DNA-pairing protein; ALS6; Amyotrophic lateral sclerosis 6; FUS; FUS CHOP; Fus like protein; FUS-CHOP; FUS_HUMAN; FUS1; Fused in sarcoma; Fusion (involved in t(12;16) in malignant liposarcoma); Fusion derived from t(12;16) malignant liposarcoma; Fusion gene in myxoid liposarcoma; Heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; hnRNPP2; Oncogene FUS; Oncogene TLS; POMp75; RNA binding protein FUS; RNA-binding protein FUS; TLS; TLS CHOP; TLS-CHOP; Translocated in liposarcoma; Translocated in liposarcoma protein.
粘液样脂肪肉瘤蛋白FUS1抗体品牌浓度 1mg/1ml
规格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
产品类型一抗
研究领域肿瘤免疫学染色质和核信号信号转导转录调节因子表观遗传学
蛋白分子量 predicted molecular weight: 53kDa
性状 Lyophilized or Liquid
免疫原 KLH conjugated synthetic peptide derived from human TLS
亚型 IgG
纯化方法 affinity purified by Protein A
储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

粘液样脂肪肉瘤蛋白FUS1抗体品牌产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq].
Function : Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
Subunit : Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.
Subcellular Location : Nucleus.
Tissue Specificity : Ubiquitous.
Post-translational modifications : Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
DISEASE : Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.
Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.
Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.
Amyotrophic lateral sclerosis 6 (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the RRM TET family.
Contains 1 RanBP2-type zinc finger.
Contains 1 RRM (RNA recognition motif) domain.
Database links : UniProtKB/Swiss-Prot: P35637.1

粘液样脂肪肉瘤蛋白FUS1抗体品牌抗体的鉴定：
1）抗体的效价鉴定：不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2）抗体的特异性鉴定：抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3）亲和力：是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属：
兔抗单克隆抗体，鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。抗体及相关标记抗体：HRP标记抗体，Biotin标记抗体，Gold标记抗体，RBITC标记抗体，AP标记抗体,FITC标记抗体，Cy3标记抗体，Cy5标记抗体，Cy5.5标记抗体，Cy7标记抗体，PE标记抗体，PE-Cy3标记抗体，PE-Cy5标记抗体，PE-Cy5.5标记抗体，PE-Cy7标记抗体，APC标记抗体，AlexaFluor 350标记抗体，Alexa Fluor 488标记抗体，Alexa Fluor 555标记抗体，Alexa Fluor647标记抗体抗体的交叉反应：人，小鼠，大鼠，鸡，狗，猪，羊，牛，兔等...... 抗体的应用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。

PKB (Rat) 大鼠蛋白激酶BMulti-class antibodies规格： 48T
Anti-Phospho-EGFR(Thr669) 化表皮生长因子受体抗体Multi-class antibodies规格： 0.1ml
Rhesus antibody Rh MyoGEF 肌球蛋白相互作用G蛋白交换因子抗体规格 0.2ml
Ig-j(Human immunoglubin joining chain) ELISA Kit 人免疫球蛋白j链 96T
SPOP 英文名称： SPOP蛋白抗体 0.2ml
CCKBR 英文名称：促胃泌素受体抗体 0.1ml
Anti-Phospho-EGFR(Thr669) 化表皮生长因子受体抗体Multi-class antibodies规格： 0.1ml
Rabbit Anti-horse IgM/Alexa Fluor 488 Alexa Fluor 488标记的兔抗马IgM 0.1ml
FSH receptor 英文名称：促卵泡刺激素受体抗体 0.1ml
囊性纤维化跨膜转运调节因子抗体 anti-CFTR 0.1ml
Anti-OPGL/RANKL/CD254 /FITC 荧光素标记骨保护蛋白配体抗体IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh PKC delta 蛋白激酶C亚性D型抗体规格 0.2ml
Rabbit Anti-pig IgM/HRP 辣根过氧化物酶标记兔抗猪IgMMulti-class antibodies规格： 0.1ml
QGY-7703(人肝癌细胞) 5×106cells/瓶×2
原代心肌细胞特制无血清添加剂Many types of cells包装：1ml
HGF Others Mouse 小鼠 HGF / Hepatocyte Growth Factor 人细胞裂解液 (阳性对照)
HUVEC(原代)细胞，人脐静脉血管内皮细胞 HPVl6 E6、E7和ras基因共转化的C57BL/C(H-2b)小鼠肺上皮细胞,TC-1细胞人雪旺细胞总RNAHSC NA
小鼠诱导性多潜能干细胞;PUMC-mips-B2
Eca-109(人食管癌细胞) 5×106cells/瓶×2 CL-0246YAC-1(小鼠淋巴瘤细胞)5×106cells/瓶×2 中国仓鼠肺细胞;V79
大鼠纤维母细胞;1/EJ 1-1
MERTK Others Human 人 MERTK / Mer (aa 578-872) 杆状病毒-昆虫细胞裂解液 (阳性对照)
肝窦内皮细胞Many types of cells包装：5 × 105次方(1ml)
小鼠神经干细胞小鼠骨骼肌肌肉母细胞，Sol8细胞 S-180(腹水瘤细胞)
人脑瘤细胞;SF17
CST3 Others Mouse 小鼠 CST3 / Cystatin-C / Cystatin-3 人细胞裂解液 (阳性对照)
粘液样脂肪肉瘤蛋白FUS1抗体品牌QGY-7703(人肝癌细胞) 5×106cells/瓶×2
原代心肌细胞特制无血清添加剂Many types of cells包装：1ml
HGF Others Mouse 小鼠 HGF / Hepatocyte Growth Factor 人细胞裂解液 (阳性对照)
HUVEC(原代)细胞，人脐静脉血管内皮细胞 HPVl6 E6、E7和ras基因共转化的C57BL/C(H-2b)小鼠肺上皮细胞,TC-1细胞人雪旺细胞总RNAHSC NA
小鼠诱导性多潜能干细胞;PUMC-mips-B2
Eca-109(人食管癌细胞) 5×106cells/瓶×2 CL-0246YAC-1(小鼠淋巴瘤细胞)5×106cells/瓶×2 中国仓鼠肺细胞;V79
粘液样脂肪肉瘤蛋白FUS1抗体品牌实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在生产上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。