• 产品名称Anti-CBX1 / HP1 beta抗体
  参阅全部 CBX1 / HP1 beta 一抗
• 描述
  兔多克隆抗体to CBX1 / HP1 beta
• 特异性ab10478 recognises a band at 25 kDa, which is attributed to CBX1 / HP1 beta.
• 经测试应用WB, IHC-P, ICC/IF, IPmore details
• 种属反应性
  与反应: Mouse, Rat, Human, Marsupials
  预测可用于: Chicken, Hamster, Fruit fly (Drosophila melanogaster)
• 免疫原

  Synthetic peptide, conjugated to KLH, derived from within residues 150 to the C-terminus of Human HP1 beta.

  参阅Abcam的专有抗源政策

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• 阳性对照
  • This antibody gave a positive signal in the following lysates: HeLa Whole Cell, HeLa Nuclear, A431 Whole Cell, MCF7 Whole Cell, HEK293 Whole Cell, PC12 Whole Cell

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• 浓度Batch dependent within range: 100 µg 浓度为 0.6 - 1 mg/ml

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• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Chromatin Binding Proteins
  • Methyl Lysine

应用

靶标

• 功能Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
• 组织特异性Expressed in all adult and embryonic tissues.
• 序列相似性Contains 2 chromo domains.
• 翻译后修饰Not phosphorylated.
  Ubiquitinated.
• 细胞定位Nucleus. Unassociated with chromosomes during mitosis.
• Information by UniProt
• 数据库链接
  • Entrez Gene: 10951 Human
  • Entrez Gene: 12412 Mouse
  • Entrez Gene: 360609 Rat
  • Omim: 604511 Human
  • SwissProt: P83916 Human
  • SwissProt: P83917 Mouse
  • Unigene: 77254 Human
  • Unigene: 29055 Mouse
• 别名
  • CBX 1 antibody
  • CBX antibody
  • Cbx1 antibody

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