一种有效且具有选择性的 ATP 竞争性细胞周期蛋白依赖性激酶 9 (CDK9) 探针，可抑制 CDK9/CycT 活性，IC50 值为 0.514 nM。
NVP-2 is a strong, remarkably selective CDK9 inhibitor with an equally potent CDK10/CycM inhibitor. NVP-2 represents a highly promising starting point to design analogs that will hopefully inhibit selectively CDK10/CycM. inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases.