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试剂描述：

产品名称：LT175

产品别名：LT175

CAS号：862901-87-9

英文别名：LT175

分子量：318.4

分子式：C₂₁H₁₈O₃

纯度：≥98%

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保存方法：Store at -20℃

描述：Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC₅₀s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively).¹ It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice.¹ LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPARγ.¹

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