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  3. Anti-RAS (A146V) Mouse Monoclonal Antibody点突变

Anti-RAS (A146V) Mouse Monoclonal Antibody点突变

¥4800
NewEastbio
美国
2021-07-15 23:28
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武汉纽斯特生物技术有限公司

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武汉纽斯特生物技术有限公司
乐先生
15071267082 027-87561033
neweastbio@126.com
929192314
产品属性
抗体名RAS(A146V)抗体
抗体英文名RAS(A146V) Antibody
靶点H-Ras; K-Ras; N-Ras
浓度1mg/ml
应用范围ELISA, WB, IHC
宿主Mouse
适应物种脊椎动物
保质期2年
抗原来源Mouse
目录编号26479
级别试验级
数量300000
供应商NewEastbio
标记物FITC
克隆性单克隆
保存条件-20℃
形态液体
亚型IgG
免疫原A synthetic peptide from the internal region of Ras which includes the mutation of A146V, human origin.
规格100μl
产品说明
Ras (A146V) [26479]
[100ul]
Catalog Number: 26479
Gene Symbol: H-Ras; K-Ras; N-Ras
Description: Anti-RAS (A146V) Mouse Monoclonal Antibody
Background: The A146V mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146V mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
Immunogen: A synthetic peptide from the internal region of Ras which includes the mutation of A146V, human origin.
Applications: ELISA, WB, IHC
Recommended Dilutions:
ELISA: 1:1000-1:5000 
WB: 1:500-1:1000 
IHC: 1:50-1:100
Concentration: 1 mg/ml
Host: Mouse
Format: Liquid
Clonality: Monoclonal
Isotype:
Purity: Purified from ascites
Storage buffer:
Preservative: no
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes A146V mutant, but not wild-type RAS of vertebrates.
Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
Download Datasheet:
Western blot:
Western blot analysis of recombinant Ras (A146V) and wild-type proteins. Purified His-tagged Ras (A146V) protein (lane 1) and corresponding wild-type protein (lane 2) were blotted with anti-Ras (A146V) monoclonal antibody (Cat. #26479).
Immunofluorescence:
Immunofluorescence of cells expressing KRas proteins with anti-KRas (A146V) antibody. HEK293T cells were transfected with pCDNA3-GFP-KRas (A146V) plasmid, pCDNA3-GFP-KRas (WT) plasmid, pCDNA3-GFP-KRas (A146P) plasmid or pCDNA3-GFP-KRas (A146T) plasmid, then fixed and stained with anti-KRas (A146V) monoclonal antibody (Cat. #26479).
Publications:
1.DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
Gene Therapy 21, 888-896 (October 2014)
2.Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma
J Clin Pathol. 2015 Aug;68(8):657-60. doi: 10.1136
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