本公司提供科研Syntrophins/SNTA1/Syntrophin Alpha1神经肌肉接头蛋白SNTA1抗体，抗体质量可靠，订购Syntrophins/SNTA1/Syntrophin Alpha1神经肌肉接头蛋白SNTA1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：神经肌肉接头蛋白SNTA1抗体
英文名称：Anti-Syntrophins/SNTA1/Syntrophin Alpha1
货号：bs-3600R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, hrs, pig, cow, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Syntrophins are structurally related proteins located at the neuromuscular synapse and play an important role in dystrophin associated protein (DAP) complex formation. To date there have been three distinct syntrophin isoforms discovered: alpha 1, beta 1, and beta 2. These proteins each contain a PDZ domain, a syntrophin-unique domain (SU), and three pleckstrin homology domains (PH1a,1b and 2). The PDZ domain has been shown to be responsible for binding syntrophin to nNOS and the DAP complex. This association results in localization of the nicotinic acetylcholine receptor to the cytoskeleton via the (S/T)XV C terminus. Function : Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).Subunit : Monomer and homodimer. Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin and calmodulin. Interacts with dystrophin protein DMD and related proteins DTNA and UTRN and with MAPK12, TGFA and GA.Subcellular Location : Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.Tissue Specificity : High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.Post-translational modifications : Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD.DISEASE : Defects in SNTA1 are the cause of long QT syndrome type 12 (LQT12) [MIM:612955]. A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.Similarity : Belongs to the syntrophin family.Contains 1 PDZ (DHR) domain.Contains 2 PH domains.Contains 1 SU (syntrophin unique) domain.