本公司提供科研NEC2/Proprotein Convertase 2神经内分泌转化酶2抗体，抗体质量可靠，订购NEC2/Proprotein Convertase 2神经内分泌转化酶2抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：神经内分泌转化酶2抗体
英文名称：Anti-NEC2/Proprotein Convertase 2
货号：bs-11533R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 71kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The subtilisin-like prohormone convertase (PC) family mediates the cleavage of latent precursor proteins into their biologically active forms. This is a tightly regulated process that leads to the generation of various active peptides and proteins, including neuropeptides, polypeptide hormones, protein tyrosine phosphatases, growth factors and their receptors, and enzymes such as matrix metalloproteases (MMPs). These processing reactions occur at pairs of basic amino acids. The members of the PC family include furin, PC1/3, PC2, PC4, PACE4, PC5/6, and PC7/8 (also designated lymphoma proprotein convertase or LPC), all of which share homology to the bacterial subtilisin and yeast kexin families of endoproteases. PC1/3, also designated neuroendocrine 1 (NEC1), and PC2, also designated neuroendocrine 2 (NEC2), are widely expressed in neuroendocrine tissues, and are principally involved in the processing of hormonal and neural peptides. The human PC2 gene maps to chromosome 20p11, and is expressed in pancreatic islets, pituitary, and brain as a precursor protein and a mature form. Cleavage of proPC2 is dependent upon its interaction with 7B2, a cofactor that acts as both an activator and inhibitor of PC2 function. Proteins processed by PC2 include proglucagon, prosomatostatin, proinsulin, and pro-islet amyloid polypeptide.Function : Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.Subcellular Location : CytoplasmicSimilarity : Belongs to the peptidase S8 family. Furin subfamily.