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  3. 去泛素化酶基因载体库，dubiquitin，DUB family

去泛素化酶基因载体库，dubiquitin，DUB family

¥1000 - 3000
SUNVBIO
中国
2021-07-21 21:05
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深圳市上为生物科技有限公司

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深圳市上为生物科技有限公司
张小姐
13342984003
xiaoyingzhang@sunvbio.com
1562726985
产品属性
数量10000
供应商上为生物
保存条件-20℃
产品说明

去泛素化酶（DUBs）,是一类数量很大的蛋白酶类家族。它主要通过水解泛素羧基末端的酯键、肽键或异肽键，将泛素分子特异性的从链接有泛素的蛋白质或者前体蛋白水解下来。人类基因组编码近100种去泛素酶，使得它们成为泛素系统酶中最大家族。在人类中的去泛素化酶基因，可分为两大类：半胱氨酸蛋白酶家族和金属蛋白酶家族。半胱氨酸蛋白酶家族包含一些泛素特异型加工蛋白酶（USPs），泛素羧基末端端水解酶（UCHs），Machado-Josephin结构域蛋白酶（MJDS）和卵巢肿瘤相关蛋白酶（OTU）。金属蛋白酶家族只包含MPN(+)/JAMM蛋白酶家族。 

去泛素化酶在泛素化途径中扮演重要的角色，在泛素-蛋白酶系统中已泛素化的蛋白底物，通过裂解切断泛素链与底物蛋白之间的连接及泛素化链之间的连接，使泛素分子从蛋白质底物中脱离出来。



去泛素化酶基因家族一共有100多个，本公司现已将接近200个基因克隆构建至慢病毒载体，新的基因持续克隆更新中。

载体骨架是慢病毒载体：


表. 去泛素化酶基因载体列表。
The Human DUB Superfamily Tree
Family编号Namelength/bpNCBI Reference Sequence
USP FAMILYL1USP152995NM_001252078.1NP_001239007.1
L2USP42942NM_003363.3NP_003354.2
L3USP112942NM_004651.3NP_004642.2
L4USP324897NM_032582.3NP_115971.2
L5USP64293NM_001304284.1NP_001291213.1
L6USP83414NM_005154.4NP_005145.3
L7USP194023NM_006677.2NP_006668.1
L8USP211728NM_001014443.2NP_001014443.1
L9USP21850NM_004205.4NP_004196.4
L10USP314128NM_020718.3NP_065769.3
L11USP433430NM_153210.4NP_694942.3
L12USP50*1023NM_203494.4NP_987090.2
L13USP39*1728NM_001256725.1NP_001243654.1
L14USP202792NM_001008563.4NP_001008563.2
L15USP332878NM_015017.4NP_055832.3
L16USP162515NM_001032410.1NP_001027582.1
L17USP452487NM_001080481.1NP_001073950.1
L18USP31591NM_006537.3NP_006528.2
L19USP512173NM_201286.3NP_958443.1
L20USP221606NM_015276.1NP_056091.1
L21USP27X1340NM_001145073.2NP_001138545.1
L22USP102438NM_005153.2NP_005144.2
L23USP171616NM_201402.2NP_958804.2
L24USP363430NM_001321291.1NP_001308220.1
L25USP423981NM_032172.2NP_115548.1
L26USP442176NM_001042403.2NP_001035862.1
L27USP492103NM_001286554.1NP_001273483.1
L28USP121132NM_182488.3NP_872294.2
L29USP461120NM_022832.3NP_073743.2
L30USP353107NM_020798.3NP_065849.1
L31USP383181NM_032557.6NP_115946.2
L32USP372988NM_020935.2NP_065986.2
L33USP262787NM_031907.1NP_114113.1
L34USP292815NM_020903.2NP_065954.1
L35USP132635NM_003940.2NP_003931.2
L36USP52619NM_001098536.1NP_001092006.1
L37CYLD2921NM_015247.2NP_056062.1
L38USP483162NM_032236.7NP_115612.4
L39USP141512NM_005151.3NP_005142.1
L40USP474199NM_001330208.1NP_001317137.1
L41USP403772NM_018218.2NP_060688.1
L42USP73365NM_003470.2NP_003461.2
L43USP301579NM_032663.4NP_116052.2
L44USP181138NM_017414.3NP_059110.2
L45USP411094XM_017029164.1XP_016884653.1
L46USP253318NM_001283042.2NP_001269971.1
L47USP283287NM_020886.3NP_065937.1
L48USP3410818NM_014709.3NP_055524.3
L49USP247994NM_015306.2NP_056121.2
L50USP9X7841NM_001039590.2NP_001034679.2
L51USP9Y7795NM_004654.3NP_004645.2
L52USP12397NM_003368.4NP_003359.3
L53USP52*3661NM_001127460.2NP_001120932.1
L54USPL13333NM_005800.4NP_005791.3
L55USP53*3275NM_019050.2NP_061923.2
L56USP54*5139NM_152586.3NP_689799.3
UCH FAMILYL57UCHL1683NM_004181.4NP_004172.2
L58UCHL3705NM_006002.4NP_005993.1
L59UCHL51007NM_015984.4NP_057068.1
L60BAP12226NM_004656.3NP_004647.1
JOSEPHIN FAMILYL61ATXN31104NM_004993.5NP_004984.2
L62ATXN3L1086NM_001135995.1NP_001129467.1
L63JOSD1619NM_001360235.1NP_001347164.1
L64JOSD2576NM_001270639.1NP_001257568.1
OTU FAMILYL65OTUD43400XM_005263079.4XP_005263136.1
L66HIN1L**1351GenBank: BN000160.1
L67OTU1827NM_017670.2NP_060140.2
L68OTUD11470NM_001145373.2NP_001138845.1
L69OTUD51744NM_017602.3NP_060072.1
L70OTUD31216NM_015207.1NP_056022.1
L71OTUD6A881NM_207320.2NP_997203.1
L72OTUD6B896NM_016023.4NP_057107.4
L73OTUB1829NM_017670.2NP_060140.2
L74OTUB2716NM_023112.3NP_075601.1
L75VCPIP3722NM_025054.4NP_079330.2
L76TRABID2157NM_017580.2NP_060050.2
L77A202407NM_001270508.1NP_001257437.1
L78Cezanne22821NM_130901.2NP_570971.1
L79Cezanne2568NM_020205.3NP_064590.2
L80FAM105*1088NM_019018.2NP_061891.1
L81OTULIN1076NM_138348.5NP_612357.4
JAMM/MPN+ FAMILYL82CSN51020NM_006837.2NP_006828.2
L83POH1947NM_005805.5NP_005796.1
L84BRCC3966NM_024332.3NP_077308.1
L85MPND1439NM_032868.5NP_116257.2
L86MYSM12528NM_001085487.2NP_001078956.1
L87EIF3H*1076NM_003756.2NP_003747.1
L88CSN6*999NM_006833.4NP_006824.2
L89PSMD7*991NM_002811.4NP_002802.2
L90EIF3F*1091NM_003754.2NP_003745.1
L91AMSH1294NM_001353967.1NP_001340896.1
L92AMSH-LP1329NM_020799.3NP_065850.1
L93PRPF8*7124NM_006445.3NP_006436.3
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