关键词：Cyclin A抗体;细胞周期蛋白A抗体;细胞周期蛋白A;CCNA1; Cyclin-A1; CCNA2; CCN1; CCNA; Cyclin-A2; Cyclin-A

中文名称：细胞周期蛋白A多克隆抗体/Cyclin A Polyclonal Antibody

英文名称：Cyclin A Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP51079.pdf

产品描述：兔抗-细胞周期蛋白A 多克隆抗体

Cyclin A1 encoded by CCNA1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for CCNA1.

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