<span style="color:#d35400;"><span style="font-size:20px;"><span style="unicode-bidi:embed"><span style="word-break:normal"><span style="font-family:微软雅黑"><span style="font-weight:bold">AAV是最安全的基因治疗病毒载体</span></span></span></span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">血清型众多，宿主范围广，适合多个组织器官的基因导入；</span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">基因表达、干预方式多样：包括表达正常基因，干扰基因，编辑基因；</span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">免疫源性低，肝毒性低，可大剂量静脉、脑组织、血管介入注射，适合全身性组织器官细胞基因修饰；</span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">不复制，不整合，可免除诱发癌症的风险；</span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">长时程基因表达，治疗效果持久，甚至可以治愈；</span></span></span><br />
<span style="font-size: 18px; font-family: Wingdings;">p</span><span style="font-size: 18px; font-family: 宋体;"><span style="color:black"><span style="font-weight:bold">可大规模标准化制造，可按照GMP标准管理。</span></span></span><br />
<img alt="" src="http://img1.dxycdn.com/2019/0422/712/3341300697374746552-14.jpg" style="width: 500px; height: 376px;" /><br />
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<span style="color:#d35400;"><span style="font-size:20px;"><span style="unicode-bidi:embed"><span style="word-break:normal"><span style="font-family:微软雅黑"><span style="font-weight:bold">枢密技术优势：新型大规模AAV病毒制备系统</span></span></span></span></span></span><br />
<span style="language:zh-CN"><span style="unicode-bidi:embed"><span style="word-break:normal"><span style="punctuation-wrap:hanging"><span style="font-size:16.0pt"><span style="font-family:宋体"><span style="color:black"><span style="language:zh-CN">枢密改进了早期的<strong>昆虫杆状病毒系统</strong>，用于制备重组AAV。</span></span></span></span></span></span></span></span><br />
<span style="font-size:18px;"><span style="font-family:Wingdings">p</span><span style="font-family:宋体"><span style="color:black"><span style="font-weight:bold">极大提升了病毒产率和稳定性，缩短了生产时间，降低了生产成本；</span></span></span><br />
<span style="font-family:Wingdings">p</span><span style="font-family:宋体"><span style="color:black"><span style="font-weight:bold">系统变量单一，适用于工业大规模生产，可线性放大到1000L；</span></span></span><br />
<span style="font-family:Wingdings">p</span><span style="font-family:宋体"><span style="color:black"><span style="font-weight:bold">实现了VLP大规模制备。</span></span></span></span><br />
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<span style="color:#d35400;"><span style="font-size:20px;"><span style="unicode-bidi:embed"><span style="word-break:normal"><span style="font-family:微软雅黑"><span style="font-weight:bold">枢密技术优势：无血清悬浮培养系统制备病毒</span></span></span></span></span></span><br />
<span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: Wingdings;">p</span><span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: 宋体;"><span style="font-weight:bold">大幅提高生产效率，降低生产成本；</span></span><br />
<span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: Wingdings;">p</span><span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: 宋体;"><span style="font-weight:bold">减少后续病毒产品纯化步骤，避免血清残留；</span></span><br />
<span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: Wingdings;">p</span><span style="color: rgb(0, 0, 0); font-size: 18px; text-align: justify; font-family: 宋体;"><span style="font-weight:bold">有利于后续药物申报和质量控制。</span></span><br />
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<span style="color:#d35400;"><span style="font-size:20px;"><span style="line-height:130%"><span style="unicode-bidi:embed"><span style="word-break:normal"><span style="font-family:微软雅黑"><span style="font-weight:bold">枢密主要合作伙伴<br />
<img alt="" src="http://img1.dxycdn.com/2019/0422/723/3341301773263749101-14.png" style="width: 500px; height: 107px;" /><br />
<img alt="" src="http://img1.dxycdn.com/2019/0422/452/3341301811918455236-14.png" style="width: 500px; height: 104px;" /></span></span></span></span></span></span></span><br />
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