产品名称：p21 rabbit Polyclonal Antibody
产品货号：ATA34821
产品规格：100ug
免疫原：Synthesized peptide derived from human p21 around the non-phosphorylation site of T145.
宿主种属：Rabbit
反应种属：Human,Mouse,Rat
产品状态：Liquid
克隆性：Polyclonal
应用实验：WB: 1/500 - 1/2000.IHC-p:1:50-300
纯化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
产品背景：cyclin dependent kinase inhibitor 1A(CDKN1A) Homo sapiens This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac
存放条件：Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4 °C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.


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