产品说明
强效微管蛋白抑制剂
该产品包含在以下化合物库中:
质量控制
化学性质
| CAS号 | 1401963-17-4 | | |
| 别名 | Vc MMAD;VcMMAD |
| 分子式 | C70H104N12O14S | 分子量 | 1369.71 |
| 溶解性 | Soluble in DMSO | 储存条件 | Store at -20° |
实验操作
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产品描述
Description: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
