产品货号 : jlcR6597 英文名称 : NPHS2/Podocin 中文名称 : 肾小球裂孔膜蛋白PDCN抗体 别名 : nephrosis 2, idiopathic, steroid resistant; NPHS2 gene; PDCN; Podocin; SRN1; PODO_HUMAN. 研究领域 : 细胞生物信号转导细胞类型标志物 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 : 42kDa 细胞定位 :细胞膜 性状 : Lyophilized or Liquid 浓度 : 1mg/ml 免疫原 : KLH conjugated synthetic peptide derived from human NPHS2/Podocin:231-330/383 <Extracellular> 亚型 : IgG 纯化方法 : affinity purified by Protein A 储存液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : Podocin is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Subunit: Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN (By similarity).
Tissue Specificity: Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.
DISEASE: Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2) [MIM:600995]. It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder.
Similarity: Belongs to the band 7/mec-2 family.
SWISS: Q9NP85
Gene ID: 7827
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
