本公司提供科研HSD17B1羟类固醇脱氢酶17β-HSD抗体，抗体质量可靠，订购HSD17B1羟类固醇脱氢酶17β-HSD抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：羟类固醇脱氢酶17β-HSD抗体
英文名称：Anti-HSD17B1
货号：bs-3855R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 35kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, dog, pig, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth. It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia.Subunit : Homodimer.Subcellular Location : Cytoplasm.Similarity : Belongs to the short-chain dehydrogenases/reductases (SDR) family.Ⅰ型17β-羟类固醇脱氢酶又称Ⅰ型17HSD，催化雌酮与雌二醇之间的转化，为性激素合成过程中最后步骤的催化酶。它催化性激素Ｃ17位上的酮基和醇基之间的还原和氧化反应 ,使低生物活性的雌酮、雄烯二酮与高生物活性的雌二醇、睾酮之间相互转化。17βHSD的结构和功能的异常与一些疾病 ,如肿瘤、假两性等的发生有密切关系.