中文名称：重组人Oncostatin M蛋白
英文名称：Recombinant Human Oncostatin M Protein
品 牌：北京同立海源生物


重组人 Oncostatin M 蛋白（Human Oncostatin M Protein） 作用机理：
Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The three dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF.


重组人 Oncostatin M 蛋白（Human Oncostatin M Protein） 产品信息：
【同源名称】：OSM、MGC20461
【表达宿主】：人 HEK293 细胞
【产品货号】：GMP-TL683
【蛋白序列】：DNA 序列编码人 Oncostatin M（NCBI Reference Sequence:NP_065391.1）表达带有 His 标签在C 末端。
【分 子 量 】：重组人 Oncostatin M 蛋白包含 227 个氨基酸，预测理论分子量为 27.5 kd。
【纯度】：≥95%采用SDS-PAGE凝胶和高效液相色谱分析。
【内毒素】： ＜0.1EU/ug（凝胶法）
【生物活性】：使用人 TF-1 细胞检测细胞增殖分析，该作用的 ED ₅₀ 是 0.1-0.5ng/mL。
【提纯方法】：层析纯化
【组成】：含有 6%甘露醇的无菌 PBS（PH 7.4）的冻干粉
【性状】：白色疏松体
【保存温度】：2-8℃


重组人 Oncostatin M 蛋白（Human Oncostatin M Protein） 使用说明：
稳定性和储存：冻干的样本的可以在 4℃保存 24 个月，溶解后的液体可以于-20℃保存 6-12 个月，并且避免反复冻融。

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