| 保存条件 | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| 数量 | 货期：1-2天 |
| 供应商 | MedChemExpress LLC |
| CAS号 | 1835283-94-7 |
| 规格 | 10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg |
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CAS No. : 1835283-94-7
MCE 国际站：Pan-RAS-IN-1
产品活性：Pan-RAS-IN-1是一种pan-Ras抑制剂，破坏Ras蛋白及其作用子的相互作用。
研究领域：GPCR/G Protein
作用靶点：Ras
In Vitro: Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range. At some concentrations, pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment.
In Vivo: Pan-RAS-IN-1 administration results in inhibition of tumor growth over 15 days of treatment. Pan-RAS-IN-1-treated mice exhibits decreased tumor pERK levels compared with vehicle treated mice. A modest increase in cleaved caspase-3 is also observed, showing that in this model, pan-RAS-IN-1 has the capacity to induce caspase activation.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Ferroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | BI-2852 | NSC 23766 trihydrochloride | Ketoconazole | ML141 | Rhosin hydrochloride | EHT 1864 | CASIN | EHop-016 | Salirasib | CID-1067700 | GGTI298 | LC-2 | CCG-1423 | CCG-203971 | Y16 | Kobe0065 | Deltarasin | ML-098 | Digeranyl bisphosphonate | K-Ras-IN-1 | Z62954982 | KRAS inhibitor-9 | MLS000532223 | Antineoplaston A10 | ARS-1323-alkyne | Kobe2602 | K-Ras G12C-IN-1 | K-Ras G12C-IN-3 | Methylophiopogonanone B
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