产品描述：RANK ligand (RANKL) is a cytokine that binds to TNFRS11B/OPG and to TNFGS11A/RANK This cytokine also augments the ability of dendritic cells to stimulate naïve T-cell proliferation, is an important regulator of interactions between T-cells and dendritic cells, and plays a role in the regulation of the T-cell-dependent immune response. RANKL is an osteoclast differentiation and activation factor and enhances bone resosrption in humoral hypercalcemia of malignancy. Recombinant human soluble RANKL produced in E. coli is a single non-glycosylated polypeptide chain containing 176 amino acids with a MW of 20,006 Da.
形 态 ：Each vial contains 10 ug protein lyophilized in 10 mM sodium phosphate pH8.0. Reconstitute with 0.1 ml sterile deionized water for a final concentration of 0.1 mg/ml.
来 源 ：E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
别 名 ：tumor necrosis factor ligand superfamily member 11; receptor activator of nuclear factor kappa B ligand RANKL; TNF-related activation induced cytokine; TRANCE; osteoprotegerin ligand; OPGL; osteoclast differentiation factor; ODF; CD254; Tumor necrosis factor ligand superfamily member 11, membrane form; tumor necrosis factor ligand super family member 11, soluble form; TNFSF11; OPGL; RANKL
纯 度 ：Purity > 98% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
分子量 ：20006 Da
应 用 ：E, WB
RANK ligand is fully biologically active when compared to standard. The activity is determined by its ability to induce osteoclast formation in RAW264.7 cells using a conc. of 5.0-10.0 ng/ml and by dose dependant stimulation of IL-8 production in human PBMC.
保存条件 ：Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
产品链接 ：http://www.abbiotec.com/proteins/human-rank-ligand 
