AP-26113,AP26113,26113价格,详情介绍-960化工网

AP-26113,AP26113,26113

价格：￥1500

品牌：active biochem

产地：美国

最新更新日期：2021-08-11 10:28

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公司：武汉思高科技发展有限公司

联系人：肖先生

联系电话： 13476150086 13476150086

联系邮箱：john0325@163.com

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产品属性

保质期	2°C to 8 °C保存, 可在-20°C情况下保存两年

英文名	active Biochem

数量

不限

供应商	active Biochem

CAS号	1197958-12-5

保存条件	2°C to 8 °C保存, 可在-20°C情况下保存两年

规格	5mg、10mg、20mg、50mg、100mg、200mg、500mg、1g、5g及以上

产品说明

产品描述：
AP-26113 is a novel orally available, and potent dual kinase inhibitor of ALK and EGFR.
AP26113 is an anaplastic lymphoma kinase (ALK) inhibitor. It is designed to overcome resistance mutations in ALK, specificially the ALK-L1196M mutation that results in resistance to another ALK inhibitor, crizotinib (PFE).
AP26113 also inhibits activated EGFR in preclinical models, including the T790M "gatekeeper" mutant that confers resistance to current EGFR inhibitors. Constitutive EGFR activity due to activating mutation is a key feature of certain non-small cell lung cancers, and the T790M mutation causes resistance to inhibitor therapy in approximately 50 percent of these cases. AP26113 has shown to be specific for mutated EGFR and avoids inhibition of native (endogenous or unmutated) EGFR; such inhibition is thought to be associated with the toxicity of other EGFR inhibitors.

M.Wt（分子量）: 529.01
CAS#（CAS编号）:1197958-12-5
Formula（化学式）:C26H34ClN6O2P
Chemical Purity（化学纯度）: >99%
Storage Conditions（存储条件）: 2ºC to 8 ºC保存, 可在-20ºC情况下保存两年

价格
5mg	10mg	20mg	50mg	100mg
1700	2500	3300	5000	7000
联系方式：john0325@163.com

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