关键词：PDC6I抗体;细胞程序性死亡蛋白6相互作用蛋白抗体;细胞程序性死亡蛋白6相互作用蛋白;Programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95

中文名称：细胞程序性死亡蛋白6相互作用蛋白多克隆抗体/PDC6I Polyclonal Antibody

英文名称：PDC6I Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP59854.pdf

产品描述：兔抗-细胞程序性死亡蛋白6相互作用蛋白多克隆抗体

PDCD6IP encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of PDCD6IP binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of PDCD6IP product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for PDCD6IP. Related pseudogenes have been identified on chromosome 15.

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