| Background: | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Applications: | WB |
| Name of antibody: | GAB2(Ab-623) |
| Immunogen: | Synthesized non-phosphopeptide derived from human Gab2 around the phosphorylation site of serine 623 (P-S-S(p)-P-S). |
| Full name: | GRB2-associated binding protein 2 |
| Synonyms： | KIAA0571 |
| SwissProt: | Q9UQC2 |
| WB Predicted band size: | 74 kDa |
| WB Positive control: | COS cells lysate |
| WB Recommended dilution: | 500-3000 |
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