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TPI-1

CAS No. : 79756-69-7

MCE 国际站：TPI-1

产品活性：TPI-1是SHP-1的抑制剂；抑制重组SHP-1的IC₅₀值为40 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ⁺ cells and induces IFNγ⁺ cells in human peripheral blood.

In Vivo: TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ⁺ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.

相关产品：Clinical Compound Library | Clinical Compound Library Plus | Anti-Cancer Compound Library | Metabolism/Protease Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Cyclosporin A | Tacrolimus | SHP099 | Ebselen | Salubrinal | Suramin sodium salt | RMC-4550 | Calyculin A | MSI-1436 lactate | DT-061 | β-Glycerol phosphate disodium salt pentahydrate | Sodium orthovanadate | TNO155 | GSK 2830371 | NSC 663284 | SF1670 | LB-100 | Pentamidine isethionate | Microcystin-LR | Sal003 | Sodium metatungstate | Sodium stibogluconate | 3α-Aminocholestane | BCI | D-erythro-Sphingosine | NSC-87877 | Rosiptor | ARL67156 trisodium salt

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