| 保存条件 | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| 数量 | 货期：7天 |
| 供应商 | MedChemExpress LLC |
| CAS号 | 126150-97-8 |
| 规格 | 10 mM * 1 mL/5 mg/10 mg/50 mg |
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CAS No. : 126150-97-8
MCE 国际站：BAPTA-AM
产品活性：BAPTA-AM 是一种可透过细胞膜的钙螯合剂 (Ca2+ chelator)。在 HEK 293 细胞中，BAPTA-AM 阻断 hERG，hKv1.3 和 hKv1.5 通道，IC50 分别为 1.3，1.45 和 1.23 μM。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Potassium Channel
In Vitro: BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+.
BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage.
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