基质金属蛋白酶-9抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
基质金属蛋白酶-9抗体产品介绍
合成与降解（Synthesis and Degradation）
MMP9亦称IV型胶原酶或明胶酶B，其主要功能为降解IV型胶原。因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。
目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与转移浸润的研究。细胞外基质在维持正常组织结构与功能以及细胞生长和分化过程中起重要作用。细胞外基质动态平衡的失调与肿瘤细胞侵袭、转移和复发密切相关，基质金属蛋白酶(MMP-9)是细胞外基质的降解酶，可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型胶原，在肿瘤的浸润、转移过程中起重要作用，近年为肿瘤研究的热点。
Kiss-1与MMP-9、MMP-2 是转移浸润研究的热门课题。
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn(2+) binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
Also known as:
Matrix metalloproteinase-9 precursor; MMP-9; 92 kDa type IV. Collagenase; 92 kDa gelatinase; Gelatinase B; GELB;xy-9039R PDZD5APDZ结构域PDZK5A蛋白抗体
xy-5423R PPAP2A磷酸脂磷酸水解酶1抗体
xy-4592R P14ARF抑癌基因p16/p14/P19抗体
xy-9187R PTPH1蛋白酪氨酸磷酸酶H1抗体
xy-5587R phospho-PI 3 Kinase p110 delta (Tyr524)磷酸化磷脂酰肌醇激酶催化亚单位D抗体
xy-5643R phospho-RAD9(Ser277)磷酸化细胞周期检查控制蛋白质抗体
xy-7128R Perforin穿孔素抗体
xy-13674R PALM3PALM3抗体
xy-5107R PON1芳香酯酶1(对氧磷酶)抗体
xy-5108R PNPO磷酸吡哆醇氧化酶抗体
xy-5565R phospho-PRKCB(Ser660)磷酸化蛋白激酶C抗体
xy-5566R phospho-PRKCB(Ser642)磷酸化蛋白激酶C抗体
xy-5567R Phospho-PTEN(Ser385)磷酸化肿瘤抑制基因PTEN抗体
xy-5570R phospho-PI3KCA(Tyr317)磷酸化磷脂酰肌醇激酶催化亚单位A抗体
xy-5571R phospho-PIK3R1(Tyr467)磷酸化磷脂酰肌醇激酶抗体
xy-5572R phospho-PIK3R1(Tyr556)磷酸化磷脂酰肌醇激酶抗体
xy-5573R phospho-PRKCA(Ser657+Tyr658)磷酸化蛋白激酶C抗体
xy-5574R phospho-PRKCA(Thr637)磷酸化蛋白激酶C抗体
xy-5575R phospho-AMPK alpha 2 (Ser173)磷酸化腺苷单磷酸活化蛋白激酶α2抗体
xy-4158R SHP1蛋白酪氨酸磷酸酶1C抗体
xy-5577R phospho-PTPN6(Tyr536)磷酸化蛋白酪氨酸磷酸酶1C抗体
xy-5578R phospho-PTPN6(Ser591)磷酸化蛋白酪氨酸磷酸酶1C抗体
xy-4159R PI 3 Kinase Class 3磷脂酰肌醇激酶3催化亚单位3抗体
xy-5580R phospho-PIK3C3(Ser676)磷酸化磷脂酰肌醇激酶3催化亚单位3抗体
xy-5581R phospho-PIK3C3(Ser164)磷酸化磷脂酰肌醇激酶3催化亚单位3抗体
基质金属蛋白酶-9抗体
