本公司提供科研phospho-APP/ABPP (Thr743)磷酸化APP淀粉样肽前体蛋白抗体，抗体质量可靠，订购phospho-APP/ABPP (Thr743)磷酸化APP淀粉样肽前体蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化APP淀粉样肽前体蛋白抗体
英文名称：Anti-phospho-APP/ABPP (Thr743)
货号：bs-5167R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 76kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, cow, dog, pig, chk
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. Immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP is expressed in the brain, kidney, heart and spleen of fetal tissues; it is induced during neuronal differentiation. In adult brain, highest expression of APP is found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer's disease (AD). Phosphorylation of APP at Tyr757 and 762 is important for MAPK8IP1, APBA1, shcA/shcC and DAB1 binding. Binding interactions regulated by phosphorylation determine the localisation and the function of APP. Therefore Amyloid Precursor Protein (phospho Y757) antibody will be a useful tool in tracing the processing, distribution and interaction of APP.