本公司提供科研Tal1T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体，抗体质量可靠，订购Tal1T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
英文名称：Anti-Tal1
货号：bs-9428R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, cow, chk, pig, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors. Subunit : Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.Subcellular Location : Nucleus.Tissue Specificity : Leukemic stem cell.Similarity : Contains 1 basic helix-loop-helix (bHLH) domain.