产品英文名称：
Recombinant Human PM/Scl 100

英文简称:
PM/Scl 100

中文名称:
重组人PM/Scl100蛋白

背景资料:
PM/Scl 100 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome"， which is an RNA-processing complex consisting of a number of exoribonucleases （not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes）.Autoantibodies against PM/Scl 100 occur in patients su昆虫Sf9细胞中重组表达ering from polymyositis， scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex （PM/Scl 75， several Rrp proteins） can be found in some sera， practically all patients with autoantibodies against the PM/Scl complex are positive for PM/Scl 100 antibodies， making this specificity an important marker. The presence of PM/Scl 100 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis sPM/Scl 100 Human Recombinant produced in SF9 is a glycosylated， polypeptide chain having a molecular mass of 120 kDa.PM/Scl 100 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.n when other myositis and systemic sclerosis specific autoantibodies are present.

产品描述:
PM/Scl 100 Human Recombinant produced in SF9 is a glycosylated， polypeptide chain having a molecular mass of 120 kDa.PM/Scl 100 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
来源宿主:
昆虫Sf9细胞中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. PM/Scl 100is supplied at a concentration of 0.8mg/ml in 20mM HEPES， pH-7.5， 100mM NaCl， 0.01mM EDTA， 0.02% SDS.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。