本公司提供科研ACVRL1/ALK1激活素受体样激酶1抗体，抗体质量可靠，订购ACVRL1/ALK1激活素受体样激酶1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：激活素受体样激酶1抗体
英文名称：Anti-ACVRL1/ALK1
货号：bs-6020R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, pig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.Function : On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.Subcellular Location : Membrane.DISEASE : Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain.Contains 1 protein kinase domain.