本公司提供科研Ctip2B淋巴细胞白血病/淋巴瘤11B抗体，抗体质量可靠，订购Ctip2B淋巴细胞白血病/淋巴瘤11B抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：B淋巴细胞白血病/淋巴瘤11B抗体
英文名称：Anti-Ctip2
货号：bs-11545R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 95kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, pig, cow, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.Function : Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.Subunit : Interacts with TFCOUP1, SIRT1, ARP1 and EAR2Subcellular Location : Nucleus.Tissue Specificity : Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.Similarity : Contains 6 C2H2-type zinc fingers.