产品货号 : jlcR5992 英文名称 : BRCAA1 中文名称 : 乳腺癌相关抗原BRCAA1抗体 别名 : ARID 4B; ARID domain-containing protein 4B; ARID4B; AT rich interactive domain 4B (Rbp1 like); AT rich interactive domain 4B; BCAA; BRCAA 1; BRCAA1; Breast cancer associated antigen 1; Breast cancer associated antigen BRCAA 1; Breast cancer associated antigen BRCAA1; Breast carcinoma associated antigen; Histone deacetylase complex subunit SAP180; Rb binding protein homolog; RBBP1 L1; RBBP1L1; Rbp 1 like; Rbp1 l1; Rbp1 like; RBP1 like protein; RBP1L; Rbp1l1; Retinoblastoma binding protein 1 like 1; SAP 180; SAP180; SIN3A associated protein 180; ARI4B_HUMAN. 研究领域 : 肿瘤细胞生物免疫学染色质和核信号细胞类型标志物 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Chicken, Dog, Cow, Horse, 产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 : 148kDa 细胞定位 : 细胞核细胞浆 性状 : Lyophilized or Liquid 浓度 : 1mg/ml 免疫原 : KLH conjugated synthetic peptide derived from human BRCAA1:21-120/1312 亚型 : IgG 纯化方法 : affinity purified by Protein A 储存液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Subunit: Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.
Subcellular Location: Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells.
Tissue Specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
Similarity: Contains 1 ARID domain.
SWISS: Q4LE39
Gene ID: 51742
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
