本公司提供科研RBBP5视网膜母细胞瘤结合蛋白5抗体，抗体质量可靠，订购RBBP5视网膜母细胞瘤结合蛋白5抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：视网膜母细胞瘤结合蛋白5抗体
英文名称：Anti-RBBP5
货号：bs-6016R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 59kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, chk, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：RbBP5, retinoblastoma binding protein 5, belongs to a highly conserved subfamily of WD proteins and contains 6 WD repeats. It binds preferentially to underphosphorylated retinoblastoma protein, which is involved in the control of cell proliferation. RbBP5 is a component of the SET1 complex and of MLL containing complexes. RbBP5 is phosphorylated in response to DNA damage, probably by ATM/ATR.Function : As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.Subunit : Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL, MLL2/ALR, MLL3 and MLL4/WBP7), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A.Subcellular Location : Nucleus.Tissue Specificity : Ubiquitously expressed.Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.Similarity : Contains 6 WD repeats.