本公司提供科研SH2D1A/SAP信号传导T淋巴细胞活化相关蛋白抗体，抗体质量可靠，订购SH2D1A/SAP信号传导T淋巴细胞活化相关蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：信号传导T淋巴细胞活化相关蛋白抗体
英文名称：Anti-SH2D1A/SAP
货号：bs-9873R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 16kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).Subcellular Location : Cytoplasmic