化合物简介

我来翻译
Norethisterone (INN, BAN), also known as norethindrone (USAN), as well as 19-nor-17α-ethynyltestosterone, but more commonly known under its trade name Utovlan®, is a steroidal progestin used in some combined oral contraceptive pills and progestogen-only pills, and also available as a standalone drug. It can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia. Norethisterone was the first orally highly active progestin to be synthesized.
It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. It was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications. Norethisterone was first introduced, as Norlutin, in 1957.

基本信息

纠错

中文名称：

炔诺酮

中文别名：

17α-乙炔基-17β-羟基-19-去甲-4-雄甾烯-3-酮;

19诺塞睾甾酮;

17α-乙炔基-19-去甲睾酮;

17α-Ethynyl-19-nortestosterone;

4-19-去甲基雄烯二醇;

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英文名称：

norethisterone

英文别名：

Mini-Pe;

Norethindrone;

Noriday;

Norfor;

triella;

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CAS号：

68-22-4

分子式：

C20H26O2

分子量：

298.41900

精确质量：

298.19300

PSA：

37.30000

LogP：

3.49250

物化性质

纠错

外观与性状：

灰白色至淡黄色固体

密度：

1.15 g/cm3

熔点：

205-206 °C(lit.)

沸点：

447ºC at 760 mmHg

折射率：

1.577

储存条件：

-20ºC Freezer