【Molecular Wt.】10 kDa

【Description】Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

【Species Reactivity】Human;Mouse

【Tested applications】WB;ICC;IF;IHC

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】Recombinant protein

【Positive control】Mouse thymus tissue lysate, Hela, HUVEC, human tonsil tissue, human breast cancer tissue, human lung caner tissue.

【Conjugate】Non-conjugated

【Alternative names】Beta chemokine RANTES antibody
Beta chemokine RANTES precursor antibody
C C motif chemokine 5 antibody
CCL 5 antibody
CCL5 antibody
CCL5_HUMAN antibody
Chemokine (C C motif) ligand 5 antibody
Chemokine CC Motif Ligand 5 antibody
D17S136E antibody
EoCP antibody
Eosinophil chemotactic cytokine antibody
MGC17164 antibody
RANTES(4-68) antibody
Regulated upon activation normally T expressed and presumably secreted antibody
SCYA 5 antibody
SCYA5 antibody
SIS delta antibody
SIS-delta antibody
SISd antibody
Small inducible cytokine A5 (RANTES) antibody
Small inducible cytokine A5 antibody
Small inducible cytokine subfamily A (Cys Cys) member 5 antibody
Small-inducible cytokine A5 antibody
T cell specific protein p288 antibody
T cell specific RANTES protein antibody
T cell-specific protein P228 antibody
T-cell-specific protein RANTES antibody
TCP 228 antibody
TCP228 antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Secreted.

【Background References】1. Liu Y et al. TWEAK/Fn14 Activation Participates in Ro52-Mediated Photosensitization in Cutaneous Lupus Erythematosus. Front Immunol 8:651 (2017).
2. Fan Y et al. Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion. Mediators Inflamm 2014:397815 (2014).

【DatasheetURL】http://www.huabio.com/upload/ET1705-70.pdf

【Uniprot ID】P13501(Human) P30882(Mouse)

【Raised in】Rabbit

【Clone No.】JM03-45