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本试剂(GO 6976)
仅供科研实验使用,不得用于其他用途！
简介：
货 号：G-6203
名 称：GO 6976
别 名：GO 6976
C A S ：136194-77-9
分子量：378.43
分子式：C24H18N4O
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 25 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
文 献：Novel, very potent PKC inhibitor with high selectivity for the A-group of PKC isotypes (α, β, and γ), with IC50 values in the 2-10 nM range. Little or no inhibition of the B- and C-groups of PKC isotypes, even at much higher concentrations. Kleinschroth, J., Hartenstein, J., Rudolph, C. and Schächtele, C. "Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C." Bioorg. Med. Chem. Lett. 3: 1959-1964 (1993). Martiny-Baron, G., Kazanietz, M.G., Mischak, H., Blumberg, P., Kochs, G., Hug, H., Marme, D. and Schächtele, C. "Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976." J. Biol. Chem. 268: 9194-9197 (1993).
