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Go 6983

CAS No. : 133053-19-7

MCE 国际站：Go 6983

产品活性：Go 6983 是一种有效的 PKC 抑制剂，能够作用于 PKCα，PKCβ，PKCγ，PKCδ 和 PKCζ，IC₅₀ 值分别为 7 nM，7 nM，6 nM，10 nM 和 60 nM。

研究领域：Epigenetics | TGF-beta/Smad

作用靶点：PKC

In Vitro: Go 6983 inhibits PKCμ with IC₅₀ of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC₅₀ values from 7 to 60 nM. Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts. Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99%.

相关产品：Reprogramming Compound Library | Kinase Inhibitor Library | Oxygen Sensing Compound Library | Anti-Cancer Compound Library | Epigenetics Compound Library | Bioactive Compound Library Plus | TGF-beta/Smad Compound Library | Cytoskeleton Compound Library | Phorbol 12-myristate 13-acetate | Staurosporine | Ionomycin | Midostaurin | Fasudil Hydrochloride | Mitoxantrone | Bisindolylmaleimide I | Sotrastaurin | Rottlerin | Enzastaurin | Chelerythrine chloride | Ingenol Mebutate | LXS196 | Ro 31-8220 mesylate | Afuresertib | Ruboxistaurin hydrochloride | CGP60474 | Phorbol 12,13-dibutyrate | TPPB | Verbascoside | D-erythro-Sphingosine | K-252a | DCP-LA | HA-100 | Daphnetin | Valrubicin | (-)-Indolactam V

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