【Molecular Wt.】70kDa

【Description】Human Complement C3 (C3) is synthesized as a single-chain pro-molecule (185 kDa) that tsuffers several posttranslational modifications. Before being a mature protein, C3 is split into beta-chain (70 kDa) and alpha chain (115 kDa) and forms a rare internal thioester bond. C3 plays a central role in the activation of the complement system. It’s processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.

【Species Reactivity】Human

【Tested applications】WB;ICC;FC

【Antibody type】Mouse monoclonal Antibody

【Immunogen】peptide

【Positive control】Human plasma

【Conjugate】Non-conjugated

【Alternative names】Acylation-stimulating protein cleavage product antibody
AHUS5 antibody
ARMD9 antibody
ASP antibody
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody
C3 antibody
CO3_HUMAN antibody
Complement C3 antibody
Complement C3 beta chain antibody
Complement C3c alpha' chain fragment 2 antibody
Complement component 3 antibody
Complement component C3 antibody
Complement factor 3 antibody
CPAMD1 antibody
Plp antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG2b

【Purity】Protein A purified.

【Subcellular location】secrete

【Background References】1. Structure of C3b reveals conformational changes that underlie complement activity."Janssen B.J.C., Christodoulidou A., McCarthy A., Lambris J.D., Gros P.Nature 444:213-216(2006)
2. Disulfide bridges in human complement component C3b."Dolmer K., Sottrup-Jensen L.FEBS Lett. 315:85-90(1993)
3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003)

【DatasheetURL】http://www.huabio.com/upload/M0809-14.pdf

【Uniprot ID】P01024

【Raised in】Mouse

【Clone No.】11-10