【Molecular Wt.】53 kDa

【Description】Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

【Species Reactivity】Human

【Tested applications】WB;ICC/IF;IHC;FC

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】recombinant protein

【Positive control】SKOV-3, Hela, HepG2, human kidney tissue, human lung tissue.

【Conjugate】Non-conjugated

【Alternative names】DBP antibody
DBP/GC antibody
GC antibody
Gc globulin antibody
Gc-globulin antibody
GRD3 antibody
Group specific component antibody
Group specific component vitamin D binding protein antibody
Group-specific component antibody
hDBP antibody
VDB antibody
VDBG antibody
VDBP antibody
Vitamin D binding alpha globulin antibody
Vitamin D-binding protein antibody
VTDB_HUMAN antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Secreted.

【Background References】1. Ackermann AM et al. Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Mol Metab 5:233-44 (2016).
2. Tao W et al. Hormonal induction and roles of Disabled-2 in lactation and involution. PLoS One 9:e110737 (2014).

【DatasheetURL】http://www.huabio.com/upload/ET1703-09.pdf

【Uniprot ID】P02774(Human)

【Raised in】Rabbit

【Clone No.】JM10-36