分子量：
94948 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.2. Cesare, P. et al. (1999)Proc. Natl. Acad. Sci. U.S.A.96, 7658.3. Kim, J. et al. (2003) Nature 424, 81.4. Ahern, G. P. et al. (2003) J. Biol. Chem. 278, 30429.5. Ross, R.A. et al. (2003) Br. J. Pharmacol. 140, 790.6. Tominaga, M. et al. (1998) Neuron 21, 531.7. Vlachova, V. et al. (2003) J. Neurosci. 23, 1340.8. Agopyan, N. et al. (2004) Am. J. Physiol. 286, L563.9. Reilly, C.A. et al. (2003) Toxicol. Sci. 73, 170.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality TRPV1 antibody.
功能：

总结：
TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6Other members of this family, TRPV2, TRPV3 and TRPV4 also show thermal sensitivity.7Conformational changes in the C-terminus are responsible for many functions such as permeation and gating.There is also evidence that deletion of the C-terminus causes a loss of sensitivity to any stimuli.7Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9
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