产品英文名称：
Recombinant Human Fibroblast Growth Factor Receptor-4

英文简称:
FGFR4

中文名称:
重组人成纤维细胞生长因子受体-4

背景资料:
Fibroblast growth factors （FGFs） comprise a family of at least eightSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.n structurally related proteins that are involved in a multitude of physiological and pathological cellular processes， including cell growth， di昆虫细胞中重组表达erentiation， angiogenesis， wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors， FGF R1 - 4， are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide， thrSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques. immunoglobulin （Ig）-like domains， an acid-box region containing a run of acidic residues betwSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.n the IgI and IgII domains， a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all thrSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques. Ig domains， referred to as the a isoform， or only IgII and IgIII， referred to as the b isoform. Only the a isoform has bSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.n identified for FGF R3 and FGF R4. Additional splicing events for FGF R1 - 3， involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons， generate FGF receptors with alternative IgIII domains （IIIb and IIIc）. A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also bSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.n reported for FGF R1. Mutations in FGF R1 - 3 have bSoluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.n found in patients with birth defects involving craniosynostosis. The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.

产品描述:
Soluble FGFR-4a （IIIc） Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric， glycosylated， Polypeptide chain and having a molecular mass of 170 kDa.The FGFR4 is purified by proprietary chromatographic techniques.
来源宿主:
昆虫细胞中重组表达

序列:


溶解建议:
提供的人成纤维细胞生长因子受体-4（FGFR4）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人成纤维细胞生长因子受体-4（FGFR4）的溶液（不含添加剂）中过滤灭菌并冻干产生的.我们建议加无菌的PBS以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议：
人成纤维细胞生长因子受体-4（FGFR4）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。