本公司提供科研Heparanase乙酰肝素酶抗体，抗体质量可靠，订购Heparanase乙酰肝素酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：乙酰肝素酶抗体
英文名称：Anti-Heparanase
货号：bs-1541R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 43kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, pig, dog, hrs
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.Subunit : Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1.Subcellular Location : Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Tissue Specificity : Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase.Similarity : Belongs to the glycosyl hydrolase 79 family.乙酰肝素酶(heparanase)在血管形成、炎性反应、组织生长发育及肿瘤转移的过程中起着重要作用。在正常情况下,乙酰肝素酶的分泌和活性必须受到严格的调控,以免其表达对细胞外基质错误切割造成组织损伤而发生各种病理改变。